43 articles - From Friday Sep 22 2023 to Friday Sep 29 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Liver Transpl |
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meta-analyses and systematic reviews
| Am J Clin Nutr |
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Inter-individual differences in children's short term energy compensation: a systematic review and meta-analysis. Alternative approaches to the use of COMPx are recommended to allow better characterization of children's energy compensation ability. Registered on PROSPERO: CRD42020197748. |
| J Crohns Colitis |
Patient Reported Outcome Measures in Ileoanal Pouch Surgery: a Systematic Review. There is lack of standardisation for use of PROMs in IPAA. Complexity of UC and of outcomes after IPAA demands a change in clinical practice and follow up given how crucial PROMs are, compared to their non-routinary use. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia. We found a positive association between linear growth velocities at al intervals between 0-6 years and kidney volume. Greater growth between 0-6 years of development was positively associated with kidney size and greater growth velocity after 2 years was associated with higher serum cystatin C level. |
Cross-sectional measurement of adherence to a proposed sustainable and healthy dietary pattern among U.S. adults using the newly developed Planetary Health Diet Index for the United States. The PHDI-US is a new tool that can assess adherence to the Planetary Health Diet and identify key aspects of U.S. adults' diets that could be altered to potentially help improve dietary sustainability and quality. |
Lipid-based nutrient supplements for prevention of child undernutrition: when less may be more. The current evidence suggests that MQ-LNS offers no added benefits over SQ-LNS, although further studies directly comparing MQ-LNS to SQ-LNS would be useful. One possible explanation is incomplete consumption of the MQ-LNS ration and thus lower than desirable intake of certain nutrients. Registry PROSPERO CRD42022382448 REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OR META-ANALYSES Registered with PROSPERO as CRD42022382448 on December 18, 2022 |
Low-Fat Diet Redux at W.H.O. Moreover, substitution of carbohydrates for unsaturated fat can increase insulin resistence and cardiometabolic disease, especially among populations with highly prevalent insulin resistance. In this context, the recent World Health Organization conditional recommendation to carry forward the guidance to limit dietary fat to <30% seems ill-advised and should be reconsidered. |
Omega-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies. Biomarkers of n-6 fatty acids including LA and AA were not associated with incident AF. These findings suggest that overall effects of n-6 PUFAs on influencing AF development are neutral. |
| Inflamm Bowel Dis |
Brain-Gut Axis: Invasive and Noninvasive Vagus Nerve Stimulation, Limitations, and Potential Therapeutic Approaches. Considering the importance of VN function in the brain-gut axis, VNS is a promising treatment option for IBD. This review discusses the potential therapeutic advantages and drawbacks of VNS, particularly the use of noninvasive transcutaneous auricular vagus nerve stimulation. |
Childhood Socioeconomic Characteristics and Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study. In this prospective Scandinavian cohort study, low maternal educational level was, independent of other SES and covariates, significantly associated with later IBD in her child. Further research is needed to elucidate factors that may mediate this relationship. |
Endoscopically Active Ulcerative Colitis Is Associated With Asymptomatic Atherosclerotic Vascular Disease: A Case-Control Study. Patients with UC with active mucosal inflammation showed a significantly increased odds of asymptomatic femoral or carotid vascular disease when compared with control individuals. |
Gastroenterology Clinic Follow-Up Reduces Gastroenterology-Specific Readmissions Among Patients With Severe Ulcerative Colitis. Outpatient GI follow-up after UC hospitalization reduces readmissions, with the greatest reduction occurring among patients followed up within 1 week of discharge. |
Outcome of Very Early Onset Inflammatory Bowel Disease Associated With Primary Sclerosing Cholangitis: A Multicenter Study From the Pediatric IBD Porto Group of ESPGHAN. Primary sclerosing cholangitis related to inflammatory bowel disease has similar baseline characteristics whether diagnosed as VEO-IBD or thereafter. A milder disease course in terms of biliary complications characterizes VEO-PSC-IBD. |
Plant-based Diets for Inflammatory Bowel Disease: What Is the Evidence? Although initial findings appear promising, it remains unclear whether plant-based diets are an effective adjunct or sole therapy for managing inflammatory bowel disease. Future investigators should aim to conduct methodologically rigorous interventional trials with appropriate control data and consistent and meaningful outcome reporting. |
The TNF Using germ-free mice, we studied the impact of different diets on the expansion of disease-relevant pathobionts and on the severity of inflammation. In this review article, we review some of the currently available ileitis mouse models and discuss in detail the TNF |
Vascular Disease Is Associated With Differences in Brain Structure and Lower Cognitive Functioning in Inflammatory Bowel Disease: A Cross-Sectional Study. Vascular comorbidity is associated with deleterious effects on brain structure and lower cognitive functioning in IBD. These findings suggest that proper identification and treatment of vascular disease is essential to the overall management of IBD, and that certain brain areas may serve as critical targets for predicting the response to therapeutic interventions. |
| J Crohns Colitis |
HLA signatures as pathophysiological discriminants of microscopic colitis subtypes. Our results suggest CC and LC have distinct pathophysiological underpinnings, characterised by an HLA predisposing role only in CC. This challenges existing classifications, eventually calling for a re-evaluation of the utility of MC umbrella definitions. |
NLRP3 inhibition leads to impaired mucosal fibroblast function in patients with inflammatory bowel diseases. Moreover, NLRP3 inhibition in intestinal fibroblasts induced autophagy, a cellular process involved in collagen degradation. In the presented study, we demonstrate that inhibiting NLRP3 might pave the way for novel therapeutic approaches in IBD, especially to prevent the severe complication of intestinal fibrosis formation. |
Neuroimmune modulation through vagus nerve stimulation reduces inflammatory activity in Crohn's disease patients: a prospective open label study. Neuroimmune modulation via vagus nerve stimulation was generally safe and well-tolerated with a clinically meaningful reduction in clinical disease activity associated with endoscopic improvement, reduced levels of faecal calprotectin and serum cytokines, and improved quality-of-life. |
Plasminogen activator inhibitor 1 is a novel faecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases. The serum, mucosal, and faecal PAI-1 concentration correlates with the disease activity and therapeutic response in IBD, suggesting that PAI-1 could be utilized as a novel non-invasive, disease-specific faecal biomarker in the patient follow-up. |
| Liver Transpl |
Outcomes of re-referrals of patients with alcohol-related liver disease who were previously declined for liver transplantation. Patients with ALD previously declined for liver transplant can be re-referred and successfully accepted for transplantation by fulfilling the recommendations made by the multidisciplinary team. Important factors including ongoing abstinence, engagement in addiction treatment and social support are key for successful acceptance. |
| Pancreas |
Circulating Tumor DNA Is an Accurate Diagnostic Tool and Strong Prognostic Marker in Pancreatic Cancer. Our study shows that ctDNA is an accurate diagnostic tool and strong prognostic marker in patients with pancreatic cancer. The continued investigation of ctDNA will enable its implementation in clinical practice to optimize the care and survival outcomes of patients with pancreatic cancer. |
The Hospital Frailty Risk Score Predicts Poor Prognoses in Middle-Aged and Older Patients With Acute Pancreatitis: A Nationwide Retrospective Cohort Study in Japan. Our findings highlight the importance of rapid and automated frailty risk assessment using the Hospital Frailty Risk Score for the early identification of high-risk acute pancreatitis patients. |
| Pancreatology |
European' health care indicators and pancreatic cancer incidence and mortality: A mediation analysis of Eurostat data and Global Burden of Disease Study 2019. Health care environment correlates with reported incidence and mortality of pancreatic cancer. This highlights both that ameliorated socio-economic societies suffer from higher incidence but lower mortality, as well as the epidemiological bias originating from countries' diagnostic ability. |
Opioid burden in patients with inoperable pancreatic adenocarcinoma and the development of a multivariable risk prediction model for opioid use: A retrospective cohort study. Opioid use is prevalent in patients with pancreatic cancer, associated with poor prognosis, and can be predicted based on clinical and radiological variables. External validation of this predictive model is required. |
Predicting pancreatic fistula after central pancreatectomy using current fistula risk scores for pancreaticoduodenectomy and distal pancreatectomy. The derived C-FRS models show potential for accurately predicting the development of CR-POPF after CP. However, further validation studies are required to determine the most effective model. In the meantime, the Preop-D-Roberts-FRS is recommended for clinical practice due to its ease of use and preoperative predictability. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
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| J Crohns Colitis |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
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| J Crohns Colitis |
| Liver Transpl |
| Pancreas |